Protein Surface Recognition: Approaches for the Inhibition of Protein-protein Interactions for Drug Discovery

Protein Surface Recognition: Approaches for the Inhibition of Protein-protein Interactions for Drug Discovery

Author: Ernest Giralt, Mark Peczuh, Xavier Salvatella

Format: Hardcover

Pages: 288

ISBN: 9780470059050

Publisher: John Wiley & Sons Inc

Release Date: January 18, 2011

Description du Livre

A new perspective on the design of molecular therapeutics is emerging. This new strategy emphasizes the rational complementation of functionality along extended patches of a protein surface with the aim of inhibiting protein/protein interactions. The successful development of compounds able to inhibit these interactions offers a unique chance to selectively intervene in a large number of key cellular processes related to human disease."Protein Surface Recognition" presents a detailed treatment of this strategy, with topics including: an extended survey of protein-protein interactions that are key players in human disease and biology and the potential for therapeutics derived from this new perspectivethe fundamental physical issues that surround protein-protein interactions that must be considered when designing ligands for protein surfacesexamples of protein surface-small molecule interactions, including treatments of protein-natural product interactions, protein-interface peptides, and rational approaches to protein surface recognition from model to biological systemsa survey of techniques that will be integral to the discovery of new small molecule protein surface binders, from high throughput synthesis and screening techniques to "in silico" and "in vitro" methods for the discovery of novel protein ligands.

"Protein Surface Recognition" provides an intellectual "tool-kit" for investigators in medicinal and bioorganic chemistry looking to exploit this emerging paradigm in drug discovery.

Commentaires
Andrée Bédard
Je vous recommanderai à mes collègues. Leur miracle de Noël est les livres les plus précieux que nous ayons jamais achetés. Je serais perdu sans ça. Je suis complète ment époustouflé.
Gradasso Martel
Leur Miracle de Noel était le meilleur livre que j’ai jamais acheter. Leur Miracle de Noel a fait exactement ce que tu as dit qu’il faisait.
Alphonse Ratté
Je tiens à vous remercier personnellement pour vos livres exceptionnels. C’est vraiment merveilleux.
Émilie Aucoin
Mes amis sont tellement fous qu’ils ne savent pas comment j’ai tous les ebook de haute qualité qu’ils n’ont pas!
Blanchefle Morneau
Enfin, je reçois cet ebook, merci pour tous ces miracles de Noël que je peux obtenir maintenant!